Table 3a

Cost Efficacy of Universal Screening with FutureBIRTH™ @ $750 per test by Population Incidence and Detection Rate.

100% Detection Rate

PTB≦ 32w

Incidence Rate 2.30%

PTB≦ 32w

Incidence Rate 1.38%

PTB≦ 32w

Incidence Rate 0.92%

PTB≦ 32w

Incidence Rate 0.46%

Detected/

100,000

Prevented

Savings

EOP < 34w

500

80%

400

-$62,884,809

-$49,126,078

-$42,246,713

-$35,367,348

sPTB ≦ 32w

1,800

38%

684

-$107,533,023

-$84,005,594

-$72,241,879

-$60,478,164

Cost of Testing

$75,000,000

$75,000,000

$75,000,000

$75,000,000

Cost of Therapy

$50,345

$32,248

$21,498

$10,749

Net cost of screening

-$95,367,487

-$58,099,424

-$39,467,094

-$20,834,763

80% Detection Rate

PTB≦ 32w

Incidence Rate 2.30%

PTB≦ 32w

Incidence Rate 1.38%

PTB≦ 32w

Incidence Rate 0.92%

PTB≦ 32w

Incidence Rate 0.46%

Detected/

100,000

Prevented

Savings

EOP < 34w

400

80%

320

-$50,307,847

-$39,300,862

-$33,797,370

-$28,293,878

sPTB ≦ 32w

1,440

38%

547

-$86,026,418

-$67,204,475

-$57,793,503

-$48,382,532

Cost of Testing

$75,000,000

$75,000,000

$75,000,000

$75,000,000

Cost of Therapy

$42,997

$25,798

$17,199

$8,600

Net cost of screening

-$61,291,268

-$31,479,539

-$16,573,674

$-1,667,810

60% Detection Rate

PTB≦ 32w

Incidence Rate 2.30%

PTB≦ 32w

Incidence Rate 1.38%

PTB≦ 32w

Incidence Rate 0.92%

PTB≦ 32w

Incidence Rate 0.46%

Detected/

100,000

Prevented

Savings

EOP < 34w

300

80%

240

-$37,730,885

-$29,475,647

-$25,348,028

-$21,220,409

sPTB ≦ 32w

1,080

38%

410

-$64,519,814

-$50,403,356

-$43,345,127

-$36,286,899

Cost of Testing

$75,000,000

$75,000,000

$75,000,000

$75,000,000

Cost of Therapy

$32,248

$19,349

$12,899

$6,450

Net cost of screening

-$27,218,451

-$4,859,654

$6,319, 744

$17,499,142