Table S2

Clinicopathological characteristics of high grade endometrioid endometrial cancer patients before and after PSMa,No. (%)

Characteristic

Cohort before PSM

Cohort after PSM

BRCA wild type (n = 130)

BRCA mutant type (n = 45)

P Value

BRCA wild type (n = 420)

BRCA mutant type (n = 90)

P Value

Age≥65y

0.064

0.894

No

63 (48.8)

28 (65.1)

21 (63.6)

28 (65.1)

Yes

66 (51.2)

15 (34.9)

12 (36.4)

15 (34.9)

BMI≥28 kg/m2

0.005

0.897

No

32 (26.2)

20 (50.0)

16 (48.5)

20 (50.0)

Yes

90 (73.8)

20 (50.0)

17 (51.5)

20 (50.0)

Diabetes history

0.174

0.456

No

60 (65.9)

23 (79.3)

22 (71.0)

23 (79.3)

Yes

31 (34.1)

6 (20.7)

9 (29.0)

6 (20.7)

Hypertension history

0.007

0.945

No

31 (31.6)

21 (56.8)

19 (57.6)

21 (56.8)

Yes

67 (68.4)

16 (43.2)

14 (42.4)

16 (43.2)

AJCC stage

0.538

0.564

Early (stage I-II)

92 (70.8)

34 (75.6)

23 (69.7)

34 (75.6)

Advanced (stage III-IV)

38 (29.2)

11 (24.4)

10 (30.3)

11 (24.4)

Lymph node metastasis

0.733

0.406

No

95 (80.5)

34 (82.9)

24 (75.0)

34 (82.9)

Yes

23 (19.5)

7 (17.1)

8 (25.0)

7 (17.1)

Depth of myometrial invasion

0.238

0.344

<50%

53 (51.0)

16 (40.0)

13 (52.0)

16 (40.0)

≥50%

51 (49.0)

24 (60.0)

12 (48.0)

24 (60.0)

Peritoneal cytology

0.506b

0.626b

Negative

78 (88.6)

33 (94.3)

19 (90.5)

33 (94.3)

Positive

10 (11.4)

2 (5.7)

2 (9.5)

2 (5.7)

Residual disease

0.614

0.872

No

78 (76.5)

29 (80.6)

23 (82.1)

29 (80.6)

Yes

24 (23.5)

7 (19.4)

5 (17.9)

7 (19.4)

Radiation therapy use

0.695

0.927

No

59 (50.0)

20 (46.5)

15 (45.5)

20 (46.5)

Yes

59 (50.0)

23 (53.5)

18 (54.5)

23 (53.5)

Chemotherapy use

0.749

0.384

No

47 (68.1)

20 (71.4)

10 (58.8)

20 (71.4)

Yes

22 (31.9)

8 (28.6)

7 (41.2)

8 (28.6)

Molecular targeted therapy use

0.811

0.523

No

45 (60.8)

19 (63.3)

12 (54.5)

19 (63.3)

Yes

29 (39.2)

11 (36.7)

10 (45.5)

11 (36.7)

  • Abbreviations: PSM, propensity score matching; BMI, body mass index; AJCC, American Joint Committee on Cancer.

  • a For some characteristics, the values do not sum to heading totals because of missing data.

  • b Fisher's exact test, all other comparisons are by χ2 test.